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Proxy Services provide issuers of DTC-eligible securities the information they need to contact DTC participants regarding corporate-related events. 2023 This week, RuPaul gives us a treat with two rounds of the celebrity impersonation game show. Patients with Del (20q) have lower response rate and worse outcome, similar to patients with unfavorable cytogenetics.Recent Examples on the Web This week, Ru serves up a double helping of the celebrity impersonation game show, with the queens playing in two rounds, with two different casts of characters. No difference in survival was observed between patients with isolated Del (20q) and those with additional cytogenetic abnormalities: the median OS were 5 and 7.5 mos, respectively (p=0.964) (Figure 1).Ĭonclusion: Our data demonstrated that Del (20q) occurs in 2% of previously untreated AML patients, with around 63% of these patients showing complex karyotype. On the other hand, patients with Del (20q) had a significantly decreased overall survival (7.5 mos 95% CI, 7.26-7.73, p=0.002) in comparison to patients with normal karyotype (17.7 mos 95% CI, 17.64-17.71). Patients with Del (20q) were compared to the remaining patients with leukemia classified as unfavorable cytogenetic status the median survival for Del (20q) patients was similar by OS (OS 6.9 mos, 95% CI, 6.82-6.91). Objective response rates were 43% and 65% for patients with and without Del (20q), respectively (p=0.04) and the CR rates were 36% and 58%, respectively (p=0.01). Median RFS and OS for patients with Del (20q) were 16.8 and 7.5 months (mos), respectively. Patients with Del (20q) were older (p=0.04), with lower bone marrow blast numbers (p<0.001), and lower WBC (p=0.001) compared to patients without Del (20q) (Table 1). The distribution of cytogenetic abnormalities was as follows: isolated Del (20q) in 5 (14%), +8 in 3 (9%), +8 complex in 2 (6%), -5 complex in 8 (23%), -7 complex in 5 (14%), -7 not complex in 1 (3%), -5 and -7 complex in 6 (17%), other complex in 1 (3%), and other not complex in 4 (11%). Results: From a total of 1741 adult AML patients, we identified 35 with Del (20q), representing 2% of our cohort. The Kaplan-Meier product limit method was used to estimate overall survival and the log-rank tests were employed for statistical comparisons between the OS curves. OS was defined as time from hematological diagnosis to death or last follow-up and relapse-free survival (RFS) was measured from time of hematological response to relapse. Collected data included baseline demographics, number and type of additional cytogenetic abnormalities, disease characteristics, treatment and outcome. Patients and Methods: AML patients with chromosome 20 abnormalities were identified between 20 through the MD Anderson Cancer Center AML database (n=1741). Objective: The aim of this study is to determine the frequency and the impact on outcome of 20q deletion alone or with additional cytogenetic abnormalities in adult patients with AML. Multiple studies established isolated 20q deletion as a good prognostic marker in MDS, with lower AML transformation rates and longer median overall survival (OS) in comparison with complex 20q deletion. The majority of recurring chromosomal aberrations are associated with an individual prognosis, other less frequent like the Del (20q), have been minimally evaluated and classified as intermediate risk in AML. Background: Karyotype classification is one of the strongest independent prognostic indicators in AML. Some of you may know, when it comes to the performance, the trigger that changed the entire game for “MIC Drop” was J-Hope. I personally think the hero of “MIC Drop” is J-Hope. People who live like that will live like that. No more business with you, don’t apologize and let’s not see each other anymore. I wrote the bridge part, and it was truly what I wanted to say. I guess it’s because it wasn’t how you felt.” However, the rap that J-Hope wrote and it’s vibe was what we really wanted to talk about. Producer Bang heard it and said, “You better do it this way, because this rap is okay. You know, the rap part in the song, “Yeah, 누가 내 수저 더럽대 / I don’t care, 마이크 잡음 금수저 여럿 패” (“Yeah, who says my spoon is dirty? / I don’t care, when I grab the mic, I have several gold spoons”). It all started with the rap lyrics that J-Hope wrote. That was why I couldn’t write good lyrics when writing “MIC Drop” at first. You’ve said good things about me and led me to a better direction. It’s all because of you (T/N: Rm is referring to ARMYs, BTS' fandom). Now, I can accept such criticism – to a certain point – and I don’t get mad. I had a lot of weak points, and it wasn’t easy to fix my mistakes. Because of my stage name I wore sunglasses and had my hair done to try and look fierce and aggressive. You can’t be strong if you threat others, but I did. Even to me, I think my face, look or eyes are different from me when I did “No More Dream”. It felt like me when I did “No More Dream”. When we decided to write about that topic for “MIC Drop”, I brought up all my anger and frustration pent up inside, but it wasn’t cool at all. Life is too short to appreciate those things, but when people are rude and threaten others, I just… You can think of “MIC Drop” in that case. However, as for those who criticize or mock us, I feel sorry for them, because there are so many good things out there in the world. That’s why we always have to be open to constructive criticism. If you believe you’re always right, you become dogmatic. I think I have to listen to criticism more carefully, because no one in the world is perfect. “When people criticize you guys without a reason and make fun of you, what should I do? I feel so angry,” our fans told us such things a lot. Based on the letters from our fans I read, or what they told us. In an Vlive by RM, one of the members of BTS, he said:Īs for “MIC Drop”, it was really well put in our comeback show. |
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